Sloane knows better than to cry in front of anyone. With suicide now an international epidemic, one outburst could land her in The Program, the only proven course of treatment. Sloane’s parents have already lost one child; Sloane knows they’ll do anything to keep her alive. She also knows that everyone who’s been through The Program returns as a blank slate. Because their depression is gone—but so are their memories.

Under constant surveillance at home and at school, Sloane puts on a brave face and keeps her feelings buried as deep as she can. The only person Sloane can be herself with is James. He’s promised to keep them both safe and out of treatment, and Sloane knows their love is strong enough to withstand anything. But despite the promises they made to each other, it’s getting harder to hide the truth. They are both growing weaker. Depression is setting in. And The Program is coming for them.

In a society where unwanted teens are salvaged for their body parts, three runaways fight the system that would "unwind" them.
Connor's parents want to be rid of him because he's a troublemaker. Risa has no parents and is being unwound to cut orphanage costs. Lev's unwinding has been planned since his birth, as part of his family's strict religion. Brought together by chance, and kept together by desperation, these three unlikely companions make a harrowing cross-country journey, knowing their lives hang in the balance. If they can survive until their eighteenth birthday, they can't be harmed -- but when every piece of them, from their hands to their hearts, are wanted by a world gone mad, eighteen seems far, far away.
In Unwind, Boston Globe/Horn Book Award winner Neal Shusterman challenges readers' ideas about life -- not just where life begins, and where it ends, but what it truly means to be alive.